![]() ![]() ![]() As well, it has the added advantage of a 30% reduction in the amount of estrogen it contains. Studies have shown that compared to Diane, Diane-35® with the estrogen component reduced to 0.035 mg of ethinyl estradiol, is as effective in treating acne and hirsutism, and is as reliable as a contraceptive. Some of the early studies of cyproterone combined with ethinyl estradiol utilized Diane®, which is a preparation containing 0.050 mg of ethinyl estradiol. 1 When Diane-35® is used in a cyclic manner it also functions as an oral contraceptive. The Canadian indication is for the treatment of women with severe acne that is unresponsive to oral antibiotics and other available treatments, and is associated with symptoms of androgenization including seborrhea and mild hirsutism. It has recently received regulatory clearance in Canada, but has not yet been approved by the US FDA. ![]() Diane-35®, known as Dianette® in some countries, is a combination of cyproterone acetate 2 mg and ethinyl estradiol 0.035 mg. ![]()
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